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JKFN Journal of the Korean Society of Food Science and Nutrition



Online ISSN 2288-5978

Current Issue

  • Review l 2022-09-30

    Development of AI-Based Healthcare System of Precision Nutrition for Health (PNH)

    Myoungsook Lee , Sang Duk Yoon , Jieun Shin , Jihyun Kim, and Sang Hoon Lee

    The AI-based precision nutrition for health (PNH) or personalized nutrition for health (PNH) system as healthcare platform business is expanding due to the paradigm shift from disease treatment to prevention along with the development of related technology, big data and artificial intelligence (AI). In the Covid-19 era, we have learned that AI-based healthcare system is considered the first defensive line for population. The healthcare platform has good chance of success since its service is highly related to the national health promotion to prevent disease. However, to establish successful platform, we need more government support in such areas as a control tower for the database (DB) sharing and verification, investment on research infrastructure to build the clinical data for Koreans, and training for multidisciplinary experts. This review is the first report to emphasize the necessity of the AI-based PNH as healthcare platform. We suggest the future direction or research guidelines of healthcare platform development by considering merits and demerits of current healthcare systems in developed countries and proposing ways to improve them. Also, we prepare the future promising technology against fierce competition to build a DB sharing mechanism and to develop related contents and technologies.Key words : artificial intelligence (AI), precision nutrition for health (PNH), big data, healthy diet algorithm

  • Article l 2022-09-30

    The In Vitro and In Vivo Inhibitory Effect of Combined Extracts of Cervus elaphus Antler, Glycyrrhiza uralensis, and Angelica gigas on Benign Prostatic Hyperplasia

    Jeong Yoon Lee , Hyung Gu Son, So Hyuk Kim, Ki Won Lee, Jin Soo Kim, In Hwan Kim, Young Tae Koo, and Yoo-Hyun Lee

    Combinations of natural products have a number of benefits. We investigated the inhibitory effect of a combination of 50% ethanol extracts of Cervus elaphus antler (CEE), Glycyrrhiza uralensis (GUE), and Angelica gigas (AGE) on benign prostatic hyperplasia (BPH) using BPH-1 cells and testosterone propionate (TP)-induced BPH rats. The combination, called CGA113, inhibited cell proliferation by decreasing the cell viability of BPH-1 cells up to 72.03% more than the individual extracts. In addition, CGA113 significantly reduced the mRNA expressions of AR and SRD5A2 in BPH-1 cells. Sprague-Dawley rats were subjected to castration surgery to remove endogenous testosterone, and 3 mg/kg testosterone propionate was subcutaneously injected to induce BPH. Subsequently, CGA113 (50 and 200 mg/kg BW/day) was orally administered to the TP-induced BPH rats for 8 weeks. In the CGA113-H group (200 mg/kg of CGA113), the prostate ratio, serum DHT, prostate DHT, and prostate 5α-reductase2 were significantly decreased compared to the BPH group. Histology with H&E staining of the prostate tissue, revealed a reduction in the thickening of the prostate epithelial cells and enlargement of the lumen compared to the BPH group. The mRNA levels of the Bax/Bcl2 ratio in prostate tissue of the CGA113-H group were significantly increased. Overall, the combined extract of CEE, GUE, and AGE, was determined to exert synergistic effects, indicating the potential of the three natural materials as therapeutic agents for alleviation of BPH symptoms.Key words : androgen receptor, Angelica gigas, benign prostatic hyperplasia, Cervus elaphus antler, Glycyrrhiza uralensis

  • Article l 2022-09-30

    Effect of Euonymus alatus Extracts on Diabetes Related Markers in Pancreatic β-Cells and C57BL/Ksj-db/db Mice

    Ye Rin Kim , Eun-young Kim, Seong Uk Lee, Young Wan Kim, and Yoon Hee Kim

    Euonymus alatus (Thunb.) Sieb is known to have anti-cancer and anti-inflammatory effects. This study aimed to reveal the effect of the water extract and 70% ethanol (70% EtOH) extract of Euonymus alaltus in INS-1 cells (pancreatic beta cell line) and C57BL/Ksj-db/db mice (type 2 diabetes models). The water extract significantly increased the proliferation of INS-1 cells. However, the extracts of Euonymus alatus water and 70% EtOH had no effect on increasing the insulin secretion in INS-1 cells. In the animal model of type 2 diabetes, the extracts of Euonymus alatus water and 70% EtOH decreased the water intake and effectively increased the pancreatic insulin concentration. Furthermore, exposure to the 70% EtOH extract resulted in decreasing the plasma triglycerides. These data indicate that the extracts of Euonymus alatus water and 70% EtOH exert a partial anti-diabetic effect.Key words : Euonymus alatus (Thunb.) Sieb, type 2 diabetes, INS-1, C57BL/Ksj-db/db

  • Department of Biomedical Laboratory Science, Molecular Diagnostics Research Institute, Namseoul UniversityWhen blood vessels are damaged, a prompt hemostatic response follows to lower blood loss and maintain normal circulation, and platelet activation and aggregation are essential components of this response. Nevertheless, abnormal or excessive platelet aggregation underlies the etiologies of cardiovascular diseases such as thrombosis, atherosclerosis, and stroke. Therefore, the identification of substances that regulate platelet activation and suppress platelet aggregation is an important aspect of developments aimed at treating and preventing cardiovascular diseases. Artemether is a methyl ether derivative of artemisinin derived from the antimalarial plant Artemisia genus. We studied the effects of artemether on platelet functions using U46619-induced human platelets and found that artemether upregulated the cyclic adenosine monophosphate-dependent pathway and downregulated intracellular calcium mobilization, glycoprotein IIb/IIIa (αIIb/β3)-mediated signaling, and clot retraction. We suggest that artemether has effective antiplatelet and antithrombotic effects and is a potential therapeutic candidate for the prevention of platelet-induced cardiovascular disease.Key words : artemether, cAMP, intracellular Ca2+, fibrin clot

  • This study was undertaken to identify the nutrient intake and food variety by milk consumption amongst Korean postmenopausal women, using data from the Korea National Health and Nutrition Examination Survey (2013∼ 2015). A total of 1,952 postmenopausal women aged 40∼64 years were included in the survey. Milk consumption per week was determined for each subject using the semi-quantitative food frequency questionnaire. Subjects were classified into 4 groups based on milk consumption/week: Q1, no milk (n=699); Q2, >0 to ≤1 cup (n=488); Q3, >1 to ≤3 cups (n=345); and Q4, >3 cups (n=420). Intakes and index of nutritional quality (INQ) of calcium, phosphorus, and riboflavin were increased directly proportional to the milk consumption amount, and both values were the highest in Q4. Dietary variety score (DVS) and dietary diversity score (DDS, PKey words : milk, nutrient intake, nutritional quality, food, postmenopausal women

  • The quality characteristics, physiologically bioactive substance content, and antioxidant activity of different color cherry tomatoes (red, orange, yellow, and green) were measured. The moisture, crude protein, and crude fat contents of cherry tomatoes obtained were in the range 92.38∼93.34%, 0.14∼0.16%, and 0.04∼0.06%, respectively, with no difference observed according to color. Sugar content was the highest for red tomatoes (7.50 Brix) and the lowest for green tomatoes (5.80 Brix). The green tomato had the lowest pH of 4.14 and the highest acidity (0.42). Brightness (L*) was the highest in yellow tomatoes and lowest in red tomatoes. The highest values for redness and yellowness were obtained for red and yellow tomatoes, respectively. The tomato color had no effect on the total polyphenol content, but was relatively high in yellow tomato (344.19 μg GAE/g). The total flavonoid content of cherry tomatoes ranged between 62.37∼100.49 μg QE/g and showed the highest value (100.49 μg) in yellow cherry tomatoes. Lycopene was the highest in red tomatoes, and β-carotene was the highest in orange tomatoes. DPPH and ABTS radical scavenging activities were 77.39∼78.07% and 64.08∼65.24%, respectively, showing no significant difference between the colors. Taken together, the above results show that contents of flavonoids and carotenoids differed in cherry tomatoes depending on the color, but the overall antioxidant activity was high, irrespective of color.Key words : antioxidant activity, carotenoid, cherry tomato, lycopene, quality characteristic

  • This study was undertaken to determine the nutritional value of ripe and unripe pawpaw (Asimina triloba [L.] Dunal) fruits grown in Korea, for their potential application in the food industry. As the fruit ripened, soluble solids increased from 8.32°Brix to 21.10°Brix, whereas the crude fat, crude ash, crude fiber, carbohydrate, and dietary fiber contents decreased. The major free sugar detected in ripe fruit was sucrose. Most organic acids had significantly higher levels in the unripe fruit than the ripe fruit. Totally, 17 amino acids were detected in the pawpaw fruit. Compared to ripe fruits, the unripe fruits contained non-essential and other amino acids; however, the ratio of essential amino acids to total amino acids was greater in ripe fruits. The mineral contents of the unripe fruit were higher than levels obtained in the ripe fruit for all the detected components (Ca, Fe, K, and Mg). The fatty acid composition of ripe fruits showed more diversity than unripe fruits; the major fatty acids detected were linoleic acid, linolenic acid, oleic acid, and palmitic acid. The content of β-carotene was higher in ripe fruits, whereas vitamin C and E were higher in unripe fruits. Only vitamin B complex, B5, and B6 were detected, whereas B1, B2, B3, and B12 were not detected. Taken together, our results reveal that the diverse nutrients present in the pawpaw fruit, particularly in the unripe fruit, can be practically used in various food industries because of the higher nutritional value. Key words: pawpaw, Asimina triloba, fruit ripening, physicochemical properties, nutritive componentsKey words : pawpaw, Asimina triloba, fruit ripening, physicochemical properties, nutritive components

  • The objective of this study was to find out whether nitrogen stable isotopes could be used as a discrimination index for organic and non-organic vegetables such as cabbage, carrots, broccoli, peppers, and onions to enhance the consumers confidence in organic agricultural products. Analysis of the nitrogen and carbon isotope ratios revealed that the nitrogen isotope ratio of organic vegetables (n=102) and non-organic vegetables (n=88) distributed in Korea ranged between 2.9∼10.6‰ and −1.5∼4.8‰, respectively. With the exception of broccoli, the nitrogen isotope ratios of organic and non-organic vegetables differed significantly. Furthermore, analysis of the carbon isotope ratios of organic and non-organic vegetables distributed in Korea revealed that the carbon isotope ratio of organic vegetables ranged from −30.1∼−26.3‰, and inorganic vegetables ranged from −28.9∼−24.5‰. Some vegetables showing statistical significance are the result of the greenhouse effect or differences in crop photosynthesis. The distinction between carbon isotope ratios was unclear as a result of multiple analyses and comparisons of nitrogen isotope ratios and carbon isotope ratios of vegetables grown using organic and conventional farming methods. However, the nitrogen isotope ratio between organic and non-organic farming was clearly differentiated. Therefore, it is expected that the nitrogen isotope ratio can be applied as a discrimination index to determine the domestic distribution of organic products.Key words : nitrogen isotope ratio, organic, vegetable, IR-MS

  • Perilla seed meal, pressed from roasted perilla seeds, contains various polyphenols. The purpose of this study was to investigate the usability of perilla seed meal powder by baking rice cookies with 0%, 5%, 10%, 15%, and 20% of perilla seed meal powder, and analyze their anti-oxidative properties and quality characteristics. The quality characteristics such as moisture content, hardness, pH, L, a, b values, spread factor, loss rate, leavening rate, and density before baking the rice cookies showed a significant change with an increase in the amounts of perilla seed meal powder (PKey words : perilla seed meal, cookies, quality characteristics, antioxidant activities

  • Article l 2022-09-30

    Quality Characteristics of Modified Jeungpyeon with Different Amounts of Makgeolli

    Eun Seong Go , Hye Eun Woo , Ji Hye Chu , Jin Hee Choi , Hae Yeon Choi , Jong Dae Park , and Jung Min Sung

    In this study, we examined the quality characteristics of modified Jeungpyeon supplemented with different amounts of makgeolli (M30, M60, M90, M120). The quality characteristics of Jeungpyeon were investigated by its moisture content, pH, color, expansion ratio, specific volume, and texture. The Image Analyze program (Image J) was applied to investigate observations section, and pores, after which we assessed the sensory properties. Makgeolli content showed no significant difference in the moisture content for all combinations. An increase in the addition of makgeolli resulted in decreased pH, L-value, a-value, hardness, and adhesiveness of Jeungpyeon, whereas its b-value, springiness, chewiness, and gumminess increased. The expansion ratio and specific volume were the highest when the makgeolli to water ratio was 1:1 (M90). The observation with Image J showed that as the amount of makgeolli increased, the pore size became larger, and the number of pores decreased. Evaluation of the sensory properties revealed that M90 had the highest rating for all tested items, except flavor. Taken together, the results of this study suggest that modified Jeungpyeon by supplementing with M90 had a positive effect on the quality characteristics. Our results can be used as preparatory data for the standardization of modified Jeungpyeon production.Key words : Jeungpyeon, rice cake, quality characteristics, makgeolli, Image J

  • Article l 2022-09-30

    Quality Characteristics of Sweet Potato Paste Varieties Prepared by Different Heating Methods

    Ji Hyeon Yu , Hye Won Lee, Tae Hwan Shin, Yeon Jae Jo, Mi-Nam Chung, Keum Il Jang, Junsoo Lee, and Heon Sang Jeong

    This study investigated the quality characteristics of pastes prepared by different heat treatment methods using three varieties of sweet potatoes with varying colors. The free sugars, viz., fructose, glucose, and sucrose, are normally detected in the sweet potato, with additional detection of maltose when made into a paste. The total sugar content of the paste with heat treatment methods ranged between 17.61% to 20.39% for Daeyumi, 17.29% to 22.41% for Sinjami, and 14.48% to 17.66% for Juhwangmi, with the highest values obtained after being subjected to baking. The total polyphenol and flavonoid contents of the paste were highest in the Sinjami cultivar for all heat treatment methods. The extrusion force ranged from 81.24 to 140.31 N.s. and was highest in the Daeyumi variety, and in baking. Results of the sensory evaluation test revealed that baking was the most suitable heat treatment method. Moreover, our results indicate that Sinjami is valuable as a functional sweet potato paste due to its high total polyphenol and flavonoid content.Key words : sweet potato paste, heat treatment, total sugar, extrusion force, sensory evaluation

  • The objective of this study was to investigate the effects of isolated rice protein addition on the physicochemical characteristics of a meat analog. Raw material ratios were isolated rice protein: isolated soy protein (0:50, 5:45, 10:40, 15:35) with comprising wheat gluten (40%) and corn starch (10%). Extrusion conditions maintained were barrel temperature 140°C, screw speed 250 rpm, feed rate 100 g/min, and moisture content 40%. The integrity index, degree of texturization, and chewiness of the meat analog were observed to increase with increasing isolated rice protein content (up to 10%). Moreover, the water holding capacity, springiness, and cohesiveness were decreased with an increaseing the isolated rice content (up to 10%). In conclusion, we determined that adding 5~10% isolated rice protein helps improve the texture properties, but 15% isolated rice protein decreases the formation of fibrous structures.Key words : isolated rice protein, meat analog, low-moisture extrusion, fibrous structure, physicochemical characteristics

  • This study was undertaken to provide basic data for revitalizing the market and help increase the demand for sleep-improving health functional foods by identifying factors that influence the purchase intention of these products. This was a nationwide consumer survey study. Data were collected through an online self-report questionnaire from August 24 to August 31, 2021, for adults aged 19 years and over. Age (P=0.005), household income (P=0.001), the expectation of effect (PKey words : sleep-improving health functional foods, purchase intention, consumer survey, sleep health, willingness to pay

  • Article l 2022-09-30

    Protective Effect of Ethyl Acetate Fraction from Domestic Walnut (Juglans regia) against PM2.5-induced Inflammation and Apoptosis

    Jong Hyun Moon , Tae Yoon Kim , Uk Lee, Jong Min Kim, Hyo Lim Lee, Min Ji Kim, Hye Rin Jeong, Min Ji Go, Seung Gyum Joo, and Ho Jin Heo

    This study examined the protective effect of the ethyl acetate fraction from domestic walnut (Juglans regia) as a Gimcheon 1 ho (EFGC) cultivar on particulate matter (PM)2.5-induced cytotoxicity in hippocampal HT22 cells. EFGC had the highest total phenolic contents, total flavonoid contents, and total tannin contents compared to other fractions. In addition, EFGC showed significant 3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and 1,1-diphenyl- 2-picrylhydrazl (DPPH) radical scavenging activities and ferric reducing/antioxidant power (FRAP). The EFGC presented an inhibitory effect of malondialdehyde (MDA) production and acetylcholinesterase (AChE) activity. The EFGC effectively decreased intracellular reactive oxygen species (ROS) contents and cellular death on hippocampal cells against PM2.5 cytotoxicity. The EFGC improved inflammatory reaction and apoptosis by regulating protein expression, such as BCl-2, p-JNK, BAX, caspase-1, and p-NF-κB.Key words : walnut, Juglans regia, PM2.5, inflammation, apoptosis

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September, 2022
Vol.51 No.9

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Print ISSN 1226-3311 Online ISSN 2288-5978