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JKFN Journal of the Korean Society of Food Science and Nutrition



Online ISSN 2288-5978

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Journal of the Korean Society of Food Science and Nutrition 2020; 49(12): 1335-1341

Published online December 31, 2020 https://doi.org/10.3746/jkfn.2020.49.12.1335

Copyright © The Korean Society of Food Science and Nutrition.

Effect of Banana (Musa acuminate Colla) Peel Extract on the Anti-Adipogenic Activity in 3T3-L1 Adipocytes

Ryeong-Hyeon Kim, Seung-Cheol Lee, and Gyo-Nam Kim

School of Bioconvergence, Kyungnam University

Correspondence to:Gyo-Nam Kim, School of Biconvergence, Kyungnam University, Gyeongnam 51767, Korea,
E-mail: gnkim@kyungnam.ac.kr
Author information: Ryeong-Hyeon Kim (Graduate student), SeungCheol Lee (Professor), Gyo-Nam Kim (Professor)

Received: August 31, 2020; Accepted: November 8, 2020

Abstract

Banana (Musa acuminate Colla) is widely grown in tropical regions. Banana peel is normally discarded and thrown away as waste. Although several studies have reported the nutritional value of bananas, the biological activities of banana peel are relatively unknown. In this study, we investigated the anti-adipogenic activities of water and ethanol extracts of banana peel (BPE-W and BPE-E, respectively) and banana peel matured for 2 days at room temperature (MBPE-W and MBPE-E, respectively) on 3T3-L1 adipocytes. To evaluate the effects of the extracts on 3T3-L1 adipogenesis, the cells were treated with 10 and 100 μg/mL of the extracts from day 2 to day 6. Treatment with 100 μg/mL of extracts significantly inhibited lipid accumulation in 3T3-L1 adipocytes. The BPE-W and BPE-E showed strong anti-adipogenic activities compared to MBPE-W and MBPE-E. Furthermore, 3T3-L1 adipocytes treated with the extracts down-regulated the transcription factor CCAAT/enhancer binding protein beta (c/EBPβ) and peroxisome proliferator-activated receptor gamma (PPAR-γ) expressions. Taken together, our results indicate that the hydrolysis of components such as tannins in banana peel during maturation could affect the anti-adipogenic activities of banana peel extracts. The results of the study suggest a potential role for banana peel extracts as ingredients in the development of functional foods for obesity.

Keywords: adipogenesis, banana peel, maturation, obesity, 3T3-L1

Article

Article

Journal of the Korean Society of Food Science and Nutrition 2020; 49(12): 1335-1341

Published online December 31, 2020 https://doi.org/10.3746/jkfn.2020.49.12.1335

Copyright © The Korean Society of Food Science and Nutrition.

바나나(Musa acuminate Colla) 껍질 추출물의 항비만 활성

김령현․이승철․김교남

경남대학교 바이오융합학부

Received: August 31, 2020; Accepted: November 8, 2020

Effect of Banana (Musa acuminate Colla) Peel Extract on the Anti-Adipogenic Activity in 3T3-L1 Adipocytes

Ryeong-Hyeon Kim, Seung-Cheol Lee, and Gyo-Nam Kim

School of Bioconvergence, Kyungnam University

Correspondence to:Gyo-Nam Kim, School of Biconvergence, Kyungnam University, Gyeongnam 51767, Korea,
E-mail: gnkim@kyungnam.ac.kr
Author information: Ryeong-Hyeon Kim (Graduate student), SeungCheol Lee (Professor), Gyo-Nam Kim (Professor)

Received: August 31, 2020; Accepted: November 8, 2020

Abstract

Banana (Musa acuminate Colla) is widely grown in tropical regions. Banana peel is normally discarded and thrown away as waste. Although several studies have reported the nutritional value of bananas, the biological activities of banana peel are relatively unknown. In this study, we investigated the anti-adipogenic activities of water and ethanol extracts of banana peel (BPE-W and BPE-E, respectively) and banana peel matured for 2 days at room temperature (MBPE-W and MBPE-E, respectively) on 3T3-L1 adipocytes. To evaluate the effects of the extracts on 3T3-L1 adipogenesis, the cells were treated with 10 and 100 μg/mL of the extracts from day 2 to day 6. Treatment with 100 μg/mL of extracts significantly inhibited lipid accumulation in 3T3-L1 adipocytes. The BPE-W and BPE-E showed strong anti-adipogenic activities compared to MBPE-W and MBPE-E. Furthermore, 3T3-L1 adipocytes treated with the extracts down-regulated the transcription factor CCAAT/enhancer binding protein beta (c/EBPβ) and peroxisome proliferator-activated receptor gamma (PPAR-γ) expressions. Taken together, our results indicate that the hydrolysis of components such as tannins in banana peel during maturation could affect the anti-adipogenic activities of banana peel extracts. The results of the study suggest a potential role for banana peel extracts as ingredients in the development of functional foods for obesity.

Keywords: adipogenesis, banana peel, maturation, obesity, 3T3-L1

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Journal of the Korean Society of Food Science and Nutrition 2020; 49: 1335-1341https://doi.org/10.3746/jkfn.2020.49.12.1335