검색
검색 팝업 닫기

Ex) Article Title, Author, Keywords

JKFN Journal of the Korean Society of Food Science and Nutrition



Online ISSN 2288-5978

Article

home All Articles View

Journal of the Korean Society of Food Science and Nutrition 2019; 48(8): 783-801

Published online August 31, 2019

Copyright © The Korean Society of Food Science and Nutrition.

Anticancer Effect and Immunomodulatory Activity of Flavonoids and Their Mechanism

Je Hyung Lee1 and Yong Kyu Lee2

1Department of Medicine, College of Medicine, Dong A University; 2Food and Nutrition, Division of Chemical Engineering, Dongseo University

Abstract

The side effects resulting from chemotherapy for cancer treatment are mostly related to immunosuppression or reduced immunity. To prevent such side effects, many studies have started focusing on natural dietary substances that have immunomodulatory effects. Flavonoids have been a particular focus of such research because they are known, for over 20 years, to have outstanding antioxidant and anti-inflammatory effects. New molecular targets of anticancer activities continue to be discovered and a comprehensive overview of various anticancer immunity studies is soon expected, and so this current study reviews the recent study results on flavonoids (quercetin, hesperidin, epigallocatechin, genistein, luteolin, kaempferol, apigenin), their anticancer activities, their anticancer immunity, their anti-inflammatory cancer suppression activity, and the mechanism of these actions. In particular, immunomodulatory flavonoids activate effector cells like macrophages, NK cells, and neutrophil granulocytes, and these cells then infiltrate themselves into tumor to slay these malignant cancer cells. Immunomodulatory flavonoids also suppress the formation and growth of tumor by suppressing TR cells, activating TC and TH cells, increasing IFN-γ, and decreasing PD-L1, IL-1 and TLR. Fortunately, there were some recent clinical reports on flavonoids preventing cancer recurrence. However, the number of reports is not enough to support flavonoids’ clinical effects and adoption as a standard treatment, because their bioavailability is low. Despite the low bioavailability, flavonoids are highly effective and safe, and each flavonoid has different molecular targets in a cell. That is why more in-depth studies are needed to find the results of combined treatment of various flavonoids or flavonoids treatment combined with other pharmaceutical substances.

Keywords: flavonoids, anticancer effect, immunomodulatory activities, action mechanism

Article

Review

Journal of the Korean Society of Food Science and Nutrition 2019; 48(8): 783-801

Published online August 31, 2019

Copyright © The Korean Society of Food Science and Nutrition.

플라보노이드의 항암 효능과 면역중재성 항암 작용 및 기작

Anticancer Effect and Immunomodulatory Activity of Flavonoids and Their Mechanism

Je Hyung Lee*1 and Yong Kyu Lee*2

*1Department of Medicine, College of Medicine, Dong A University; *2Food and Nutrition, Division of Chemical Engineering, Dongseo University

Abstract

The side effects resulting from chemotherapy for cancer treatment are mostly related to immunosuppression or reduced immunity. To prevent such side effects, many studies have started focusing on natural dietary substances that have immunomodulatory effects. Flavonoids have been a particular focus of such research because they are known, for over 20 years, to have outstanding antioxidant and anti-inflammatory effects. New molecular targets of anticancer activities continue to be discovered and a comprehensive overview of various anticancer immunity studies is soon expected, and so this current study reviews the recent study results on flavonoids (quercetin, hesperidin, epigallocatechin, genistein, luteolin, kaempferol, apigenin), their anticancer activities, their anticancer immunity, their anti-inflammatory cancer suppression activity, and the mechanism of these actions. In particular, immunomodulatory flavonoids activate effector cells like macrophages, NK cells, and neutrophil granulocytes, and these cells then infiltrate themselves into tumor to slay these malignant cancer cells. Immunomodulatory flavonoids also suppress the formation and growth of tumor by suppressing TR cells, activating TC and TH cells, increasing IFN-γ, and decreasing PD-L1, IL-1 and TLR. Fortunately, there were some recent clinical reports on flavonoids preventing cancer recurrence. However, the number of reports is not enough to support flavonoids’ clinical effects and adoption as a standard treatment, because their bioavailability is low. Despite the low bioavailability, flavonoids are highly effective and safe, and each flavonoid has different molecular targets in a cell. That is why more in-depth studies are needed to find the results of combined treatment of various flavonoids or flavonoids treatment combined with other pharmaceutical substances.

Keywords: flavonoids, anticancer effect, immunomodulatory activities, action mechanism