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JKFN Journal of the Korean Society of Food Science and Nutrition



Online ISSN 2288-5978

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Journal of the Korean Society of Food Science and Nutrition 2019; 48(3): 385-389

Published online March 31, 2019

Copyright © The Korean Society of Food Science and Nutrition.

Protective Effects of Methanol Extract from Acanthopanacis cortex Shoots against Photoaging in Human Skin Fibroblast

Hana Lee, Seonghwa Hong, Huijin Heo, Hyeonjeong Choe, Heon Sang Jeong, and Junsoo Lee

Division of Food and Animal Sciences, Chungbuk National University

Abstract

Exposure to ultraviolet (UV) light can cause skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Ultraviolet exposure is also closely associated with down-regulation of collagen synthesis and up-regulation of matrix metalloproteinases (MMPs). In this study, we investigated the protective effects of methanol extract from Acanthopanacis cortex shoots (ACS) against UVB-induced photoaging in human skin fibroblasts (Hs68 cells). The ACS extract did not show any cytotoxicity at levels up to 50 µg/mL. The extract showed protective effects against UVB-induced (30 mJ/cm2) cell damage in a dose dependent manner. In addition, the extract significantly reduced UVB-induced generation of reactive oxygen species by 11, 18.2, and 31.6% at concentrations of 12.5, 25, and 50 µg/mL, respectively, when compared to UVB-irradiation alone. The extract prevented decreases in collagen levels by inhibiting the increases in MMP-1 and MMP-3 levels caused by exposure to UVB-irradiation in Hs68 cells. Taken together, these data indicate that methanol extract from ACS exerts anti-photoaging activities and therefore has the potential for use in cosmeceutical preparations.

Keywords: photoaging, fibroblast, collagen, Acanthopanax cortex shoots

Article

Note

Journal of the Korean Society of Food Science and Nutrition 2019; 48(3): 385-389

Published online March 31, 2019

Copyright © The Korean Society of Food Science and Nutrition.

피부 섬유아세포에서 광노화에 대한 오가피순 메탄올 추출물의 피부 보호 효과

Protective Effects of Methanol Extract from Acanthopanacis cortex Shoots against Photoaging in Human Skin Fibroblast

Hana Lee, Seonghwa Hong, Huijin Heo, Hyeonjeong Choe, Heon Sang Jeong, and Junsoo Lee

Division of Food and Animal Sciences, Chungbuk National University

Abstract

Exposure to ultraviolet (UV) light can cause skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Ultraviolet exposure is also closely associated with down-regulation of collagen synthesis and up-regulation of matrix metalloproteinases (MMPs). In this study, we investigated the protective effects of methanol extract from Acanthopanacis cortex shoots (ACS) against UVB-induced photoaging in human skin fibroblasts (Hs68 cells). The ACS extract did not show any cytotoxicity at levels up to 50 µg/mL. The extract showed protective effects against UVB-induced (30 mJ/cm2) cell damage in a dose dependent manner. In addition, the extract significantly reduced UVB-induced generation of reactive oxygen species by 11, 18.2, and 31.6% at concentrations of 12.5, 25, and 50 µg/mL, respectively, when compared to UVB-irradiation alone. The extract prevented decreases in collagen levels by inhibiting the increases in MMP-1 and MMP-3 levels caused by exposure to UVB-irradiation in Hs68 cells. Taken together, these data indicate that methanol extract from ACS exerts anti-photoaging activities and therefore has the potential for use in cosmeceutical preparations.

Keywords: photoaging, fibroblast, collagen, Acanthopanax cortex shoots