Ex) Article Title, Author, Keywords
Online ISSN 2288-5978
Ex) Article Title, Author, Keywords
Journal of the Korean Society of Food Science and Nutrition 2019; 48(10): 1172-1177
Published online October 31, 2019
Copyright © The Korean Society of Food Science and Nutrition.
Seonghwa Hong1, Hana Lee1, Taekyoung Jeong1, Younghwa Kim2, Heon Sang Jeong1, and Junsoo Lee1
1Department of Food Science and Biotechnology, Chungbuk National University; 2School of Food Biotechnology and Nutrition, Kyungsung University
Skin is damaged by intrinsic and extrinsic factors, such as aging, ultraviolet (UV) light, and pollutants. UV irradiation induces the synthesis of matrix metalloproteinases (MMPs) and collagen degradation, which in turn causes skin photoaging and photocarcinogenesis. This study examined the anti-photoaging activity of jujube water extract (JWE) against UVB-induced damage in human fibroblast (Hs68 cells). The JWE did not show any cytotoxicity up to 50 µg/mL. Treatment with JWE prevented UVB-induced cytotoxicity in Hs68 cells. The protective effect of JWE appeared to be mediated by inhibiting intracellular reactive oxygen species by 21, 25, and 27% at a concentration of 12.5, 25.0, and 50.0 µg/mL, respectively. UVB increased the production of MMP-1/3 and decreased collagen synthesis. On the other hand, treatment of JWE attenuated the UVB-induced production of MMP-1/3 and prevented the reduction of collagen. These results suggest that JWE has a considerable inhibitory effect on the photoaging induced by UVB irradiation. This study showed that JWE could be used as a photo protective agent in cosmetic products.
Keywords: jujube, photoaging, collagen, fibroblast
Journal of the Korean Society of Food Science and Nutrition 2019; 48(10): 1172-1177
Published online October 31, 2019
Copyright © The Korean Society of Food Science and Nutrition.
Seonghwa Hong*1, Hana Lee*1, Taekyoung Jeong*1, Younghwa Kim*2, Heon Sang Jeong*1, and Junsoo Lee*1
*1Department of Food Science and Biotechnology, Chungbuk National University; *2School of Food Biotechnology and Nutrition, Kyungsung University
Skin is damaged by intrinsic and extrinsic factors, such as aging, ultraviolet (UV) light, and pollutants. UV irradiation induces the synthesis of matrix metalloproteinases (MMPs) and collagen degradation, which in turn causes skin photoaging and photocarcinogenesis. This study examined the anti-photoaging activity of jujube water extract (JWE) against UVB-induced damage in human fibroblast (Hs68 cells). The JWE did not show any cytotoxicity up to 50 µg/mL. Treatment with JWE prevented UVB-induced cytotoxicity in Hs68 cells. The protective effect of JWE appeared to be mediated by inhibiting intracellular reactive oxygen species by 21, 25, and 27% at a concentration of 12.5, 25.0, and 50.0 µg/mL, respectively. UVB increased the production of MMP-1/3 and decreased collagen synthesis. On the other hand, treatment of JWE attenuated the UVB-induced production of MMP-1/3 and prevented the reduction of collagen. These results suggest that JWE has a considerable inhibitory effect on the photoaging induced by UVB irradiation. This study showed that JWE could be used as a photo protective agent in cosmetic products.
Keywords: jujube, photoaging, collagen, fibroblast
© Journal of the Korean Society of Food Science and Nutrition. Powered by INFOrang Co., Ltd.