This study investigated the anti-obesity effects of natural material complexes. Male C57BL/6 mice were divided into four groups: a normal diet group (Nor), a high fat diet group (Con), 10 kinds of herbal medicines mixed with distilled water (SME), and mixed with sauce base (SMS). After 6 weeks, the body weight of the Con group increased and that of the SME group and the SMS group decreased. In addition, serum reactive oxygen species production was significantly decreased, and decreased alanine aminotransferase and aspartate aminotransferase were observed. Triglyceride and total cholesterol levels in serum and liver tissue were decreased, and the size of adipocytes was decreased in liver tissue of the treated group. Additionally, expression of proteins such as sterol regulatory element-binding transcription factor 1c, fatty acid synthase, and stearoyl-CoA desaturase-1 was down-regulated in the administration group. Overall, the results suggested that the mixture of 10 herbal medicines has anti-obesity effects.

Keywords: anti-obesity, sauce with herbal medicines, ROS, AMPK