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JKFN Journal of the Korean Society of Food Science and Nutrition



Online ISSN 2288-5978

Article

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Journal of the Korean Society of Food Science and Nutrition 2016; 45(10): 1508-1512

Published online October 31, 2016

Copyright © The Korean Society of Food Science and Nutrition.

Effect of Mixture Including Hot Water Extract of Houttuynia cordata Thunb on Ethanol-Induced Hangover in Rats

Yanghee You1, Hyunmi Lee2, Changsik Chung3, Min-Jae Lee3, and Woojin Jun2

1College of Human Ecology and 2Division of Food and Nutrition, Chonnam National University; 3NutriPlan Co., Ltd.

Abstract

This study was performed to investigate the ameliorating effect of a mixture of extracts from Houttuynia cordata Thunb, Nelumbo nucifera G. (leaf), and Camellia sinensis (seed) (MIX) on acute ethanol-induced hangover in Sprague-Dawley rats. Plasma ethanol and acetaldehyde levels in MIX-treated rats significantly decreased at 3 h and 5 h after acute ethanol administration (25%, 3 g/kg body weight/d) as compared to ethanol-treated rats. Hepatic alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly higher in MIX- treated rats than in ethanol-treated rats. MIX exhibited high ADH and ALDH activities on direct assays using S9 rat liver fraction for ethanol metabolic enzymes clearance action. These results suggest that MIX could alleviate ethanol-induced hangover symptoms by elevating activities related to hepatic ethanol-metabolizing enzymes against ethanol induced metabolites, and MIX should be further developed to be a new anti-hangover material.

Keywords: alcohol, acetaldehyde, alcohol dehydrogenase, acetaldehyde dehydrogenase, hangover

Article

Note

Journal of the Korean Society of Food Science and Nutrition 2016; 45(10): 1508-1512

Published online October 31, 2016

Copyright © The Korean Society of Food Science and Nutrition.

흰쥐에서 어성초 열수 추출물을 포함한 혼합물의 숙취해소 효과

Effect of Mixture Including Hot Water Extract of Houttuynia cordata Thunb on Ethanol-Induced Hangover in Rats

Yanghee You*1, Hyunmi Lee*2, Changsik Chung*3, Min-Jae Lee*3, and Woojin Jun*2

*1College of Human Ecology and *2Division of Food and Nutrition, Chonnam National University; *3NutriPlan Co., Ltd.

Abstract

This study was performed to investigate the ameliorating effect of a mixture of extracts from Houttuynia cordata Thunb, Nelumbo nucifera G. (leaf), and Camellia sinensis (seed) (MIX) on acute ethanol-induced hangover in Sprague-Dawley rats. Plasma ethanol and acetaldehyde levels in MIX-treated rats significantly decreased at 3 h and 5 h after acute ethanol administration (25%, 3 g/kg body weight/d) as compared to ethanol-treated rats. Hepatic alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly higher in MIX- treated rats than in ethanol-treated rats. MIX exhibited high ADH and ALDH activities on direct assays using S9 rat liver fraction for ethanol metabolic enzymes clearance action. These results suggest that MIX could alleviate ethanol-induced hangover symptoms by elevating activities related to hepatic ethanol-metabolizing enzymes against ethanol induced metabolites, and MIX should be further developed to be a new anti-hangover material.

Keywords: alcohol, acetaldehyde, alcohol dehydrogenase, acetaldehyde dehydrogenase, hangover