Ex) Article Title, Author, Keywords
Online ISSN 2288-5978
Ex) Article Title, Author, Keywords
Journal of the Korean Society of Food Science and Nutrition 2015; 44(6): 816-822
Published online June 30, 2015
Copyright © The Korean Society of Food Science and Nutrition.
Jae-Nam Park1, Eui-Baek Byun1,3, Jwa-Jin Kim2, Beon-Su Jang1,3, and Sang-Hyun Park1,3
1Advance Radiation Technology Institute, Korea Atomic Energy Research Institute; 2Department of Anatomy, College of Medicine, Konyang University; 3Department of Radiation Biotechnology and Applied Radioisotope Science, Korea University of Science and T
The objective of this study was to evaluate the anticancer effects of gamma-irradiated apigenin against various human cancer cells. Structural changes were analyzed by high pressure liquid chromatography. Gamma-irradiated apigenin showed a new peak distinguished from the main peak of apigenin (non-irradiated). Cytotoxic effects in human normal cells (HS68) were not observed upon gamma-irradiated and non-irradiated apigenin treatment. However, gamma-irradiated apigenin treatment significantly increased cytotoxicity against non-small lung cancer cells. For apoptosis induction activity tested by Annexin V/PI staining, gamma-irradiated apigenin showed a stronger effect than non-irradiated apigenin, and the level of reactive oxygen species was apparently elevated by gamma-irradiated apigenin treatment. These results suggest that gamma irradiation could be an effective method for development of a new physiological compound from an original compound by inducing structural changes.
Keywords: gamma irradiation, apigenin, non-small cell lung cancer, apoptosis, reactive oxygen species
Journal of the Korean Society of Food Science and Nutrition 2015; 44(6): 816-822
Published online June 30, 2015
Copyright © The Korean Society of Food Science and Nutrition.
Jae-Nam Park*1, Eui-Baek Byun*1*,*3, Jwa-Jin Kim*2, Beon-Su Jang*1*,*3, and Sang-Hyun Park*1*,*3
*1Advance Radiation Technology Institute, Korea Atomic Energy Research Institute; *2Department of Anatomy, College of Medicine, Konyang University; *3Department of Radiation Biotechnology and Applied Radioisotope Science, Korea University of Science and T
The objective of this study was to evaluate the anticancer effects of gamma-irradiated apigenin against various human cancer cells. Structural changes were analyzed by high pressure liquid chromatography. Gamma-irradiated apigenin showed a new peak distinguished from the main peak of apigenin (non-irradiated). Cytotoxic effects in human normal cells (HS68) were not observed upon gamma-irradiated and non-irradiated apigenin treatment. However, gamma-irradiated apigenin treatment significantly increased cytotoxicity against non-small lung cancer cells. For apoptosis induction activity tested by Annexin V/PI staining, gamma-irradiated apigenin showed a stronger effect than non-irradiated apigenin, and the level of reactive oxygen species was apparently elevated by gamma-irradiated apigenin treatment. These results suggest that gamma irradiation could be an effective method for development of a new physiological compound from an original compound by inducing structural changes.
Keywords: gamma irradiation, apigenin, non-small cell lung cancer, apoptosis, reactive oxygen species
© Journal of the Korean Society of Food Science and Nutrition. Powered by INFOrang Co., Ltd.