Ex) Article Title, Author, Keywords
Online ISSN 2288-5978
Ex) Article Title, Author, Keywords
Journal of the Korean Society of Food Science and Nutrition 2014; 43(4): 624-629
Published online April 30, 2014
Copyright © The Korean Society of Food Science and Nutrition.
Yongrae Lim1, Ji-Young Shin2, Hoon Kim2, Gil-Hun Baek1, Kwang-Won Yu3, Heon-Sang Jeong1, and Junsoo Lee1
1Dept. of Food Science and Technology, Chungbuk National University, Chungbuk 361-763, Korea; 2R&D Center, CosisBio Co. Ltd., Chungbuk 365-863, Korea; 3Dept. of Food and Nutrition, Korea National University of Transportation, Chungbuk 368-701, Korea
Obesity is the leading metabolic disease in industrialized countries and is closely associated with coronary heart disease, hypertension, diabetes, and cancer. The objective of this study was to evaluate the anti-adipogenic effects of two roasted coffee beans, Vietnam robusta (VR) and Ethiopia Mocha Sidamo G2 (ES), as well as fermented coffee beans with Monascus ruber (MR) mycelium on differentiation of 3T3-L1 preadipocytes. Treatments with 1,000 μg/mL of hot water extract from coffee beans significantly reduced intracellular lipid accumulation. In addition, VR more effectively inhibited transcription factors such as PPARγ, C/EBPα, FAS, and aP2 compared to ES. Further, ES fermented with MR showed more effective anti-adipogenic activity than non-fermented ES. These results suggest that VR and ES inhibit adipocyte differentiation which may contribute to their anti-adipogenic properties.
Keywords: obesity, Monascus ruber, coffee beans, 3T3-L1 cells, adipogenesis
Journal of the Korean Society of Food Science and Nutrition 2014; 43(4): 624-629
Published online April 30, 2014
Copyright © The Korean Society of Food Science and Nutrition.
Yongrae Lim*1, Ji-Young Shin*2, Hoon Kim*2, Gil-Hun Baek*1, Kwang-Won Yu*3, Heon-Sang Jeong*1, and Junsoo Lee*1
*1Dept. of Food Science and Technology, Chungbuk National University, Chungbuk 361-763, Korea; *2R&D Center, CosisBio Co. Ltd., Chungbuk 365-863, Korea; *3Dept. of Food and Nutrition, Korea National University of Transportation, Chungbuk 368-701, Korea
Obesity is the leading metabolic disease in industrialized countries and is closely associated with coronary heart disease, hypertension, diabetes, and cancer. The objective of this study was to evaluate the anti-adipogenic effects of two roasted coffee beans, Vietnam robusta (VR) and Ethiopia Mocha Sidamo G2 (ES), as well as fermented coffee beans with Monascus ruber (MR) mycelium on differentiation of 3T3-L1 preadipocytes. Treatments with 1,000 μg/mL of hot water extract from coffee beans significantly reduced intracellular lipid accumulation. In addition, VR more effectively inhibited transcription factors such as PPARγ, C/EBPα, FAS, and aP2 compared to ES. Further, ES fermented with MR showed more effective anti-adipogenic activity than non-fermented ES. These results suggest that VR and ES inhibit adipocyte differentiation which may contribute to their anti-adipogenic properties.
Keywords: obesity, Monascus ruber, coffee beans, 3T3-L1 cells, adipogenesis
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