Confirmation of Schizandrin as a Marker Compound in Jangsu Omija Powder

Yunjeong Kim*1*; *2*; Na Ha*1*; *2; Song-Hee Han*1*; *2; Ji-Young Jeon*1*; *2; Minho Hwang*1*; *2; Yong-Jin Im*1*; *2; Sun Young Lee*1*; *3; Soo-Wan Chae*1*; *2*; *4; Min-Gul Kim*1*; *2

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Journal of the Korean Society of Food Science and Nutrition 2013; 42(2): 244-248

Published online February 28, 2013

Confirmation of Schizandrin as a Marker Compound in Jangsu Omija Powder

Yunjeong Kim¹^,², Na Ha¹^,², Song-Hee Han¹^,², Ji-Young Jeon¹^,², Minho Hwang¹^,²,Yong-Jin Im¹^,², Sun Young Lee¹^,³, Soo-Wan Chae¹^,²^,⁴, and Min-Gul Kim¹^,²

¹Biomedical Research Institute, ²Clinical Trial Center, and ³Dept. of Radiatio Oncology, Chonbuk National University Hospital, Jeonbuk ⁵⁶¹-⁷¹², Korea; ⁴Dept. of Pharmacology, Chonbuk National University Medical School, Jeonbuk ⁵⁶¹-⁷¹², Korea

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We studied the development of schizandrin as a marker compound in Jangsu Omija. Schizandrin was validated for its LOD (limit of detection), LOQ (limit of quantitation), precision, accuracy, and recovery by HPLC relative to Omija powder. It showed a high linearity in the calibration curve with a coefficient of correlation (R2) of 0.9990. The LOD and LOQ were 0.2 μg/mL and 0.5 μg/mL, respectively. The intra- and inter-day precision of schizandrin calibration standards was 0.06～0.66% and 0.13～1.19%, respectively, and the intra- and inter-day accuracy of schizandrin was 98.35～103.30% and 98.35～103.00%, respectively. Overall, schizandrin was validated through our analytical methods as a marker compound in Jangsu Omija.

Keywords: schizandrin, method development, Omija, HPLC, validation

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Journal of the Korean Society of Food Science and Nutrition 2013; 42(2): 244-248

Published online February 28, 2013

HPLC를 이용한 기능성 원료 지표성분으로서 장수 오미자 분말 중 Schizandrin의 분석법 개발

Confirmation of Schizandrin as a Marker Compound in Jangsu Omija Powder

Yunjeong Kim*1*,*2*, Na Ha*1*,*2, Song-Hee Han*1*,*2, Ji-Young Jeon*1*,*2, Minho Hwang*1*,*2,Yong-Jin Im*1*,*2, Sun Young Lee*1*,*3, Soo-Wan Chae*1*,*2*,*4, and Min-Gul Kim*1*,*2

*1Biomedical Research Institute, *2Clinical Trial Center, and *3Dept. of Radiatio Oncology, Chonbuk National University Hospital, Jeonbuk 561-712, Korea; *4Dept. of Pharmacology, Chonbuk National University Medical School, Jeonbuk 561-712, Korea

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Keywords: schizandrin, method development, Omija, HPLC, validation

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Kim*1* Y, *2* , Ha*1* N, *2 , Han*1* SH, *2 , Jeon*1* JY, *2 , Hwang*1* M, *2 , Im*1* YJ, *2 , Lee*1* SY, *3 , Chae*1* SW, *2* , *4 , Kim*1* MG, *2 . Confirmation of Schizandrin as a Marker Compound in Jangsu Omija Powder. J Korean Soc Food Sci Nutr 2013;42:244-248.

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