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JKFN Journal of the Korean Society of Food Science and Nutrition



Online ISSN 2288-5978

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Journal of the Korean Society of Food Science and Nutrition 2020; 49(12): 1400-1406

Published online December 31, 2020 https://doi.org/10.3746/jkfn.2020.49.12.1400

Copyright © The Korean Society of Food Science and Nutrition.

Filtered Coffee Lowers Intestinal Cholesterol and Fat Absorption in Rats

Juyeon Kim, SoYoon Ju, and Sang Kyu Noh

Department of Food and Nutrition, Interdisciplinary Program in Senior Human Ecology, Changwon National University

Correspondence to:Sang Kyu Noh, Department of Food and Nutrition, Interdisciplinary Program in Senior Human Ecology, Changwon National University, Changwon, Gyeongnam 51140, Korea,
E-mail: sknolog@changwon.ac.kr
Author information: Juyeon Kim (Instructor), SoYoon Ju (Graduate student), Sang Kyu Noh (Professor)
*These authors contributed equally to this work

Received: October 29, 2020; Accepted: November 21, 2020

Abstract

Coffee is a complex mixture of biologically active components such as chlorogenic acids and caffeine, which may affect human health. However, there has been a long-standing controversy regarding its impact on lipid metabolism. This study was conducted to determine the role of filtered coffee in lowering intestinal absorption of cholesterol and fat in rats. Rats with lymph duct cannulae were infused with a lipid emulsion at 3.0 mL/h for 8 h via an intraduodenal catheter. The lipid emulsion contained a mixture of 33.3 kBq 14C-cholesterol, 20.7 μmol of cholesterol, 396.0 μmol of Na-taurocholate, 3.1 μmol of α-tocopherol, 452.0 μmol of triolein, and 75.4 μmol of retinol. The rats were divided into two groups, the control and the coffee group. The control group was administered lipid emulsion without filtered coffee and the coffee group was administered lipid emulsion with filtered coffee in phosphate buffered saline (pH 6.4). Lymph was collected hourly for 8 h. Filtered coffee significantly lowered the intestinal absorption of 14C-cholesterol (38.16±3.18% dose/8 h in the control group vs. 25.01±5.75% dose/8 h in the coffee group). Also, filtered coffee markedly lowered oleic acid absorption. The findings provide direct evidence that filtered coffee has a profound inhibitory effect on the intestinal absorption of cholesterol and fat.

Keywords: filtered coffee, cholesterol, fat, absorption, rat

Article

Note

Journal of the Korean Society of Food Science and Nutrition 2020; 49(12): 1400-1406

Published online December 31, 2020 https://doi.org/10.3746/jkfn.2020.49.12.1400

Copyright © The Korean Society of Food Science and Nutrition.

흰쥐에서 여과커피의 콜레스테롤과 중성지질의 소장흡수 억제 작용

김주연*․주소윤*․노상규

국립창원대학교 식품영양학과․시니어 휴먼 에콜로지 협동과정

Received: October 29, 2020; Accepted: November 21, 2020

Filtered Coffee Lowers Intestinal Cholesterol and Fat Absorption in Rats

Juyeon Kim*, SoYoon Ju*, and Sang Kyu Noh

Department of Food and Nutrition, Interdisciplinary Program in Senior Human Ecology, Changwon National University

Correspondence to:Sang Kyu Noh, Department of Food and Nutrition, Interdisciplinary Program in Senior Human Ecology, Changwon National University, Changwon, Gyeongnam 51140, Korea,
E-mail: sknolog@changwon.ac.kr
Author information: Juyeon Kim (Instructor), SoYoon Ju (Graduate student), Sang Kyu Noh (Professor)
*These authors contributed equally to this work

Received: October 29, 2020; Accepted: November 21, 2020

Abstract

Coffee is a complex mixture of biologically active components such as chlorogenic acids and caffeine, which may affect human health. However, there has been a long-standing controversy regarding its impact on lipid metabolism. This study was conducted to determine the role of filtered coffee in lowering intestinal absorption of cholesterol and fat in rats. Rats with lymph duct cannulae were infused with a lipid emulsion at 3.0 mL/h for 8 h via an intraduodenal catheter. The lipid emulsion contained a mixture of 33.3 kBq 14C-cholesterol, 20.7 μmol of cholesterol, 396.0 μmol of Na-taurocholate, 3.1 μmol of α-tocopherol, 452.0 μmol of triolein, and 75.4 μmol of retinol. The rats were divided into two groups, the control and the coffee group. The control group was administered lipid emulsion without filtered coffee and the coffee group was administered lipid emulsion with filtered coffee in phosphate buffered saline (pH 6.4). Lymph was collected hourly for 8 h. Filtered coffee significantly lowered the intestinal absorption of 14C-cholesterol (38.16±3.18% dose/8 h in the control group vs. 25.01±5.75% dose/8 h in the coffee group). Also, filtered coffee markedly lowered oleic acid absorption. The findings provide direct evidence that filtered coffee has a profound inhibitory effect on the intestinal absorption of cholesterol and fat.

Keywords: filtered coffee, cholesterol, fat, absorption, rat

Fig 1.

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Journal of the Korean Society of Food Science and Nutrition 2020; 49: 1400-1406https://doi.org/10.3746/jkfn.2020.49.12.1400