Ex) Article Title, Author, Keywords
Online ISSN 2288-5978
Ex) Article Title, Author, Keywords
Journal of the Korean Society of Food Science and Nutrition 2015; 44(7): 970-974
Published online July 31, 2015
Copyright © The Korean Society of Food Science and Nutrition.
Jung Ae Kang1,2, Seon Hye Yoon1,3, Jong Kook Rho1, Dae Seong Choi1, Beom-Su Jang1,3, and Sang Hyun Park1,3
1Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute; 2Department of Food and Nutrition, Chungnam National University; 3Department of Radiation Biotechnology and Applied Radioisotope Science, Korea University of Science and
This study was designed to evaluate the therapeutic effect of quercetin against radiation-induced hepatocellular and hematopoiectic damage in BALB/c mice. Mice were exposed to 6 Gy of γ-radiation and orally administered quercetin (25, 50 mg/kg b.w.) for 7 consecutive days. γ-Irradiation caused marked elevation of serum aspartate aminotransferase and alanine aminotransferase, levels as well as reduction of spleen index, thymus index, and the number of white blood cells. In addition, γ-irradiation induced significant elevation of lipid peroxidation as well as reduction of antioxidant enzyme activities, including superoxide dismutase, catalase, and glutathione peroxidase. However, post-treatment with quercetin resulted in a significant recovery of all of these parameters. These results suggest that quercetin acts as a potent radioprotector against irradiation-induced cellular damage in mice.
Keywords: quercetin, γ-irradiation, radioprotector, cellular damage
Journal of the Korean Society of Food Science and Nutrition 2015; 44(7): 970-974
Published online July 31, 2015
Copyright © The Korean Society of Food Science and Nutrition.
Jung Ae Kang*1*,*2, Seon Hye Yoon*1*,*3, Jong Kook Rho*1, Dae Seong Choi*1, Beom-Su Jang*1*,*3, and Sang Hyun Park*1*,*3
*1Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute; *2Department of Food and Nutrition, Chungnam National University; *3Department of Radiation Biotechnology and Applied Radioisotope Science, Korea University of Science and
This study was designed to evaluate the therapeutic effect of quercetin against radiation-induced hepatocellular and hematopoiectic damage in BALB/c mice. Mice were exposed to 6 Gy of γ-radiation and orally administered quercetin (25, 50 mg/kg b.w.) for 7 consecutive days. γ-Irradiation caused marked elevation of serum aspartate aminotransferase and alanine aminotransferase, levels as well as reduction of spleen index, thymus index, and the number of white blood cells. In addition, γ-irradiation induced significant elevation of lipid peroxidation as well as reduction of antioxidant enzyme activities, including superoxide dismutase, catalase, and glutathione peroxidase. However, post-treatment with quercetin resulted in a significant recovery of all of these parameters. These results suggest that quercetin acts as a potent radioprotector against irradiation-induced cellular damage in mice.
Keywords: quercetin, γ-irradiation, radioprotector, cellular damage
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