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JKFN Journal of the Korean Society of Food Science and Nutrition



Online ISSN 2288-5978

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Journal of the Korean Society of Food Science and Nutrition 2018; 47(3): 347-351

Published online March 31, 2018

Copyright © The Korean Society of Food Science and Nutrition.

Oral Glucose and Maltose Tolerance Test and Inhibition Effect of α-Glucosidase of Ecklonia cava Extract (Seapolynol) and Dieckol

Hui-Jeon Jeon1, Sung Ho Kim2, and Boo-Yong Lee1

1Department of Food Science and Biotechnology, College of Life Science, CHA University; 2Botamedi, Inc.

Abstract

Ecklonia cava, a brown seaweed native to the seas of Korea and Japan, includes various polyphenolic compounds. Seapolynol and its major compound dieckol derived from Ecklonia cava have various biological activities; however, their effect as a hypoglycemic agent has not been sufficiently investigated. Therefore, we investigated the effects of seapolynol and dieckol on α-glucosidase inhibition, based on the oral glucose tolerance test (OGTT) and oral maltose tolerance test (OMTT) in in vivo. α-Glucosidase inhibition activities significantly increased in response to 100 μg/mL seapolynol and 50 and 100 μM doses of dieckol. In addition, OGTT and OMTT of seapolynol and dieckol treated C57BL/KsJ-db/db mice were conducted. Specifically, seapolynol and dieckol were administrated at low and high doses for 6 weeks, after which glucose and maltose (1 g/kg body weight) were administrated orally following 12 h of starvation. Blood glucose levels were measured 30, 60, 90, and 120 min after administration of glucose and maltose. Mice that received high doses of seapolynol and dieckol showed significant 40% and 35% reductions in the area under the curve of blood glucose level, respectively. Moreover, blood glucose level of seapolynol (24.9 mmol/L) and dieckol (22.3 mmol/L) high dose groups were reduced compared to control group (31.6 mmol/L) when maltose administrated after 30 min. These results indicate that seapolynol and dieckol have the potential for use as functional materials for the treatment of hyperglycemia.

Keywords: seapolynol, dieckol, α-glucosidase inhibition activity, OGTT, OMTT

Article

Note

Journal of the Korean Society of Food Science and Nutrition 2018; 47(3): 347-351

Published online March 31, 2018

Copyright © The Korean Society of Food Science and Nutrition.

감태 추출물(Seapolynol)과 Dieckol의 α-Glucosidase 저해 활성과 포도당 및 맥아당 경구 부하 시험

Oral Glucose and Maltose Tolerance Test and Inhibition Effect of α-Glucosidase of Ecklonia cava Extract (Seapolynol) and Dieckol

Hui-Jeon Jeon*1, Sung Ho Kim*2, and Boo-Yong Lee*1

*1Department of Food Science and Biotechnology, College of Life Science, CHA University; *2Botamedi, Inc.

Abstract

Ecklonia cava, a brown seaweed native to the seas of Korea and Japan, includes various polyphenolic compounds. Seapolynol and its major compound dieckol derived from Ecklonia cava have various biological activities; however, their effect as a hypoglycemic agent has not been sufficiently investigated. Therefore, we investigated the effects of seapolynol and dieckol on α-glucosidase inhibition, based on the oral glucose tolerance test (OGTT) and oral maltose tolerance test (OMTT) in in vivo. α-Glucosidase inhibition activities significantly increased in response to 100 μg/mL seapolynol and 50 and 100 μM doses of dieckol. In addition, OGTT and OMTT of seapolynol and dieckol treated C57BL/KsJ-db/db mice were conducted. Specifically, seapolynol and dieckol were administrated at low and high doses for 6 weeks, after which glucose and maltose (1 g/kg body weight) were administrated orally following 12 h of starvation. Blood glucose levels were measured 30, 60, 90, and 120 min after administration of glucose and maltose. Mice that received high doses of seapolynol and dieckol showed significant 40% and 35% reductions in the area under the curve of blood glucose level, respectively. Moreover, blood glucose level of seapolynol (24.9 mmol/L) and dieckol (22.3 mmol/L) high dose groups were reduced compared to control group (31.6 mmol/L) when maltose administrated after 30 min. These results indicate that seapolynol and dieckol have the potential for use as functional materials for the treatment of hyperglycemia.

Keywords: seapolynol, dieckol, α-glucosidase inhibition activity, OGTT, OMTT