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JKFN Journal of the Korean Society of Food Science and Nutrition

Online ISSN 2288-5978 Print ISSN 1226-3311

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Journal of the Korean Society of Food Science and Nutrition 2020; 49(12): 1309-1318

Published online December 31, 2020 https://doi.org/10.3746/jkfn.2020.49.12.1309

Copyright © The Korean Society of Food Science and Nutrition.

Immuno-Enhancing and Anticancer Effects of Sweet Potato Peel-Based Plant Mixture

In-Seon Jeong1, Kyeong Sun Kang2, Eun-Hye Kim2, Seung Man Park1, and Mi Ja Chung2

1Hyundai F&B Co., Ltd.
2Department of Food Science and Nutrition, Gwangju University

Correspondence to:Mi Ja Chung, Department of Food Science and Nutrition, College of Health, Welfare and Education, Gwangju University, Gwangju 61743, Korea,
E-mail: mijachung@gwangju.ac.kr
Author information: Kyeong Sun Kang (Graduate student), EunHye Kim (Graduate student), Mi Ja Chung (Professor)

Received: August 31, 2020; Accepted: October 25, 2020

Abstract

This study investigated the immune-enhancing activity and anticancer effects of a sweet potato peel-based plant mixture, including Platycodon grandiflorum, Codonopsis lanceolata and corn silk, on RAW264.7 macrophages or AGS human gastric cancer cells. The products developed in this study were pouches (M3E-A) made by plant mixture extract, stick pouches (M3C-B) made using M3E-A concentrate and plant mixture tea (M3T-C). The M3A, M3B, and M3C were in the form of freeze-dried powder after the extraction and concentration of M3E-A, M3C-B, and M3T-C, respectively. The M3A, M3B, and M3C dose-dependently increased the production of nitric oxide (NO) and pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-6 in RAW264.7 macrophages. The NO and cytokine (TNF-α, IL-1β, and IL-6) levels in the M3A or M3C-treated RAW264.7 macrophages were higher than those in the M3B-treated RAW264.7 macrophages. Mice treated orally with M3C (100 mg/kg, 300 mg/kg), resulted in significantly increased splenocyte proliferation, NO levels and cytokine (INF-γ, IL-10) levels compared to control mice. The M3A, M3B, and M3C (250 to 2,000 μg/mL), respectively, inhibited the growth of AGS cells in a dose-dependent manner. These results indicate that products using sweet potato peel-based plant mixture may be used for immuno-enhancing and anticancer effects by healthy people and cancer patients.

Keywords: AGS cells, anticancer effect, immuno-enhancing effect, mouse, RAW264.7 macrophages

Article

Article

Journal of the Korean Society of Food Science and Nutrition 2020; 49(12): 1309-1318

Published online December 31, 2020 https://doi.org/10.3746/jkfn.2020.49.12.1309

Copyright © The Korean Society of Food Science and Nutrition.

고구마껍질을 주원료로 한 식물혼합물의 면역증강 및 항암효과

정인선1 ․강경순2 ․김은혜2 ․박승만1 ․정미자2

1농업회사법인 현대에프엔비(주)
2광주대학교 식품영양학과

Received: August 31, 2020; Accepted: October 25, 2020

Immuno-Enhancing and Anticancer Effects of Sweet Potato Peel-Based Plant Mixture

In-Seon Jeong1, Kyeong Sun Kang2, Eun-Hye Kim2, Seung Man Park1, and Mi Ja Chung2

1Hyundai F&B Co., Ltd.
2Department of Food Science and Nutrition, Gwangju University

Correspondence to:Mi Ja Chung, Department of Food Science and Nutrition, College of Health, Welfare and Education, Gwangju University, Gwangju 61743, Korea,
E-mail: mijachung@gwangju.ac.kr
Author information: Kyeong Sun Kang (Graduate student), EunHye Kim (Graduate student), Mi Ja Chung (Professor)

Received: August 31, 2020; Accepted: October 25, 2020

Abstract

This study investigated the immune-enhancing activity and anticancer effects of a sweet potato peel-based plant mixture, including Platycodon grandiflorum, Codonopsis lanceolata and corn silk, on RAW264.7 macrophages or AGS human gastric cancer cells. The products developed in this study were pouches (M3E-A) made by plant mixture extract, stick pouches (M3C-B) made using M3E-A concentrate and plant mixture tea (M3T-C). The M3A, M3B, and M3C were in the form of freeze-dried powder after the extraction and concentration of M3E-A, M3C-B, and M3T-C, respectively. The M3A, M3B, and M3C dose-dependently increased the production of nitric oxide (NO) and pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-6 in RAW264.7 macrophages. The NO and cytokine (TNF-α, IL-1β, and IL-6) levels in the M3A or M3C-treated RAW264.7 macrophages were higher than those in the M3B-treated RAW264.7 macrophages. Mice treated orally with M3C (100 mg/kg, 300 mg/kg), resulted in significantly increased splenocyte proliferation, NO levels and cytokine (INF-γ, IL-10) levels compared to control mice. The M3A, M3B, and M3C (250 to 2,000 μg/mL), respectively, inhibited the growth of AGS cells in a dose-dependent manner. These results indicate that products using sweet potato peel-based plant mixture may be used for immuno-enhancing and anticancer effects by healthy people and cancer patients.

Keywords: AGS cells, anticancer effect, immuno-enhancing effect, mouse, RAW264.7 macrophages

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Journal of the Korean Society of Food Science and Nutrition 2020; 49: 1309-1318https://doi.org/10.3746/jkfn.2020.49.12.1309